Excitotoxicity and stroke: Identifying novel targets for neuroprotection
نویسندگان
چکیده
منابع مشابه
Excitotoxicity and stroke: Identifying novel targets for neuroprotection
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing link between ischemia and neuronal death, and intervening the mechanistic steps that lead to excitotoxicity can prevent stroke damage. Interest in excitotoxicity began fifty years ago when monosodium glutamate was found to be neurotoxic. Evidence soon demonstrated that glutamate is not only the primary ...
متن کاملNovel mitochondrial targets for neuroprotection.
Mitochondrial dysfunction contributes to the pathophysiology of acute neurologic disorders and neurodegenerative diseases. Bioenergetic failure is the primary cause of acute neuronal necrosis, and involves excitotoxicity-associated mitochondrial Ca(2+) overload, resulting in opening of the inner membrane permeability transition pore and inhibition of oxidative phosphorylation. Mitochondrial ene...
متن کاملExcitotoxicity and neuroprotection.
BRAINSTORMS is a monthly section of The Journal of Clinical Psychiatry aimed at providing updates of novel concepts emerging from the neurosciences that have relevance to the practicing psychiatrist. From the Clinical Neuroscience Research Center in San Diego and the Department of Psychiatry at the University of California San Diego. Reprint requests to: Stephen M. Stahl, M.D., Ph.D., Editor, B...
متن کاملNeuroprotection, excitotoxicity and NMDA antagonists.
PURPOSE To analyze the main aspects of neuroprotection and excitotoxicity. DISCUSSION This is a significant theory on the pathophysiology of cerebral ischemia; it is based on the release of excitatory aminoacid (EAA), mainly glutamate. The sequence starts with a decrease of the blood flow and ends in neuronal death. The main stages of this reaction are herein presented and discussed. An in de...
متن کاملNeuroinflammation and Excitotoxicity in Neurobiology of Hiv-1 Infection and Aids: Targets for Neuroprotection
Infection with the human immunodeficiency virus-1 (HIV-1) and acquired immunodeficiency syndrome (AIDS) pose a persistent health problem worldwide. Infected peripheral immune-competent cells, in particular macrophages, appear to infiltrate the central nervous system (CNS) and provoke a neuropathological and inflammatory response involving all cell types in the brain. In fact, HIV-1 seems to ent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 2014
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2013.11.006